Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ac-VEID-CHO (trifluoroacetate salt) | 00-00-0 | 99.8% | 614.57 Da | C24H37F3N4O11 | 1 MG
Ac-VEID-CHO (TFA) is a peptide-derived reversible caspase inhibitor intended for in vitro research into apoptosis and neurodegenerative pathways. It is supplied as a trifluoroacetate salt and demonstrates potent inhibition of several executioner caspases in biochemical assays. Not for human or clinical use.
- Reversible caspase inhibitor targeting caspase-6, caspase-3, and caspase-7.
- Reported IC50 values in the low nanomolar range for primary targets.
- High purity suitable for biochemical assays (99.8%).
- Available in small mg-scale quantities for research use.
- Limited cellular activity due to poor cellular accumulation.
Medchemexpress LLC Cef20 (Tfa) | 99.3% | 1057.19 | 25 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503).
- High purity of 99.31%
- Molecular weight of 1057.19
- Solid appearance
- White to off-white color
- Sequence: Asn-Leu-Val-Pro-Met-Val-Ala-Thr-Val (NLVPMVATV)
- Soluble in DMSO
- Store in sealed container, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Pep42 TFA | 99.6% | 1335.59 | 1 MG
Pep42 TFA is a cyclic peptide ligand of GPR78. It internalizes selectively into highly metastatic human melanoma cells through a receptor-mediated process. This product is for research use only and not sold to patients.
- Cyclic peptide ligand of GPR78
- Selectively internalizes into highly metastatic human melanoma cells
Medchemexpress LLC Fsllry-nh2 tfa | 245329-02-6 | 99.7% | 910.98 | 10 MG
FSLLRY-NH2 TFA is a protease-activated receptor 2 (PAR2) inhibitor used for research purposes. Treatment with FSLLRY-NH2 has been shown to significantly improve neurological outcome and reduce the number of degenerating hippocampal neurons after ACA (asphyxial CA).
- Protease-activated receptor 2 (PAR2) inhibitor
- Significantly improves neurological outcome after cardiac arrest in rats
- Reduces degenerating hippocampal neurons after asphyxial CA
- For research use only
Medchemexpress LLC HR97 TFA | 1518.84 | 5 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops HR97-SunitiGel. The peptide-drug conjugate in HR97-SunitiGel can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Molecular weight of 1518.84 (free acid)
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Solubility in DMSO: 50 mg/mL (requires ultrasonic)
- Can be used to prepare HR97-SunitiGel eye drops
Apexbio Technology LLC CTOP TFA 1mg
CTOP TFA is a small-molecule antagonist targeting the -opioid receptor (MOR) It is designed to selectively inhibit MOR thereby regulating opioid receptor-mediated neural signaling pathways CTOP TFA exerts its biological activity primarily through specific interaction with and inhibition of MOR in the central nervous system Based on these pharmacological properties CTOP TFA holds research potential in investigating pain perception analgesia tolerance dependence neurotransmitter release stress responses and emotional regulation
Medchemexpress LLC Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Medchemexpress LLC Substance P TFA (neurokinin P TFA) | 148470-19-3 | 99.3% | 1461.65 | 25 MG
Substance P TFA (neurokinin P TFA) is a CNS-penetrant neuropeptide that functions as a neurotransmitter and neuromodulator within the central nervous system. Its endogenous receptor is the neurokinin 1 receptor (NK1-receptor, NK1R), playing a crucial role in various biological activities.
- Acts as a CNS-penetrant neuropeptide
- Functions as a neurotransmitter and neuromodulator
- Endogenous receptor is neurokinin 1 receptor (NK1R)
- Appears as a white to off-white solid
- Soluble in H2O and PBS with ultrasonic assistance
- Involved in the internalization and recycling of the NK1R complex
- Related to peptides, hormones, and neuropeptides classifications
- Associated with research in cancer, neurological, and metabolic diseases
Apexbio Technology LLC SCH772984 TFA 942183-80-4 (free base) 5mg
SCH772984 TFA is a small-molecule inhibitor targeting extracellular signal-regulated kinase 1/2 (ERK1/2) It is designed to inhibit ERK catalytic activity thereby blocking phosphorylation of downstream substrates and regulating the RAS-RAF-MEK-ERK signaling pathway SCH772984 TFA exerts its biological activity primarily through direct interaction with ERK1/2 acting as an ATP-competitive inhibitor Based on these pharmacological properties SCH772984 TFA holds research potential in studies examining ERK signaling s role in oncogenic pathway activation tumor cell growth survival mechanisms and resistance phenomena in various cancer models
Medchemexpress LLC Zifanocycline trifluoroacetate | 00-00-0 | 99.8% | 666.64 g/mol | C31H37F3N4O9 | 5 MG
Zifanocycline TFA is an orally active, semi-synthetic aminomethylcycline antibiotic supplied as the trifluoroacetate salt for research use. It inhibits bacterial ribosome function and demonstrates broad-spectrum in vitro activity against Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. Supplied at high purity for laboratory studies and antimicrobial research applications.
- Orally active aminomethylcycline antibiotic.
- Broad-spectrum activity against gram-positive and gram-negative bacteria.
- Useful for studying skin infections, community-acquired pneumonia, and intra-abdominal infections.
- High purity, suitable for analytical and biological assays.
- Provided as the trifluoroacetate (TFA) salt for improved handling.
- Molecular weight 666.64 g/mol.
Medchemexpress LLC Siynfekl Tfa | 99.9% | 1013.14 | 1 MG
SIYNFEKL TFA is a variant of the major MHC class I-restricted epitope SIINFEKL. It is an antigenic peptide that can stimulate specific T cells in experimental settings to study competitive interactions between T cells. SIYNFEKL TFA exhibits low affinity for the OT-I T cell receptor (TCR) and can be used for the detection of CD8+ T cells.
- Can stimulate specific T cells
- Used to study competitive interactions between T cells
- Exhibits low affinity for the OT-I T cell receptor (TCR)
- Can be used for the detection of CD8+ T cells
Medchemexpress LLC Cyclo(Arg-Pro) TFA | 74838-83-8 | 98.6% | 367.32 | 5 MG
Cyclo(Arg-Pro) TFA is a chitinase inhibitor that disrupts cell separation and morphological transition of yeast by inhibiting chitinase activity. It prevents cell separation of *Saccharomyces cerevisiae*, leading to the formation of grape-like cell clusters, without inhibiting cell growth. Additionally, it blocks the morphological transition of *Candida albicans* from yeast form to hyphal form, without inhibiting cell growth.
- Disrupts cell separation and morphological transition of yeast
- Prevents cell separation of *Saccharomyces cerevisiae*
- Leads to formation of grape-like cell clusters
- Blocks morphological transition of *Candida albicans* from yeast form to hyphal form
Medchemexpress LLC Biotin-COG1410 TFA | 98.0% | 1 MG
Biotin-COG1410 TFA is a biotin-labeled COG1410. COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. It exerts neuroprotective and anti-inflammatory effects in a murine model of traumatic brain injury (TBI) and can be used for the research of neurological diseases.
- Decreases the production and release of NO and TNFα in BV2 microglia cells.
- Exhibits significant improvement on vestibulomotor function and spatial learning and memory in mice.
- Improves vestibulomotor function, decreases poststroke locomotor asymmetry, and decreases infarct volume of the ipsilateral hemisphere in rats.